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SUMMARY:Molecular Imaging of Disease - Bruno Oliveira\, Chemistry Dept\, C
 ambridge
DTSTART:20180531T150000Z
DTEND:20180531T160000Z
UID:TALK106282@talks.cam.ac.uk
CONTACT:Alice Wood
DESCRIPTION:Molecular imaging is a medical discipline that aims at visuali
 zing normal and abnormal processes in living systems for the early diagnos
 is of disease. Clinical applications of molecular imaging include the use 
 of nuclear medicine (PET and SPECT imaging)\, magnetic resonance (MRI) and
  fluorescent imaging (FI) and ultrasound (US). \n\nPitfalls and remarks of
  these imaging modalities will be briefly discussed. Emphasis will be put 
 on the PET and SPECT techniques which are currently the only true "molecul
 ar" imaging methods due to their valuable quantitative capabilities. Multi
 ple agents have been developed\, predominantly for PET imaging but also fo
 r SPECT imaging. \n\nIn this talk\, we will overview various examples of i
 maging constructs\, ranging from small molecules to antibodies and nanopar
 ticles. Special attention will be given to probes for imaging thrombosis i
 n vivo which is the underlying cause of deadly diseases such as stroke\, p
 ulmonary embolism\, deep vein thrombosis and heart attack. Pre-clinical re
 sults with 64Cu-FBP8\, a PET probe that recognizes fibrin and is currently
  in clinical studies in the US\, will be presented.
LOCATION:Todd Hamied\, Department of Chemistry
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