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SUMMARY:“TissueFAXS Cytometry - A Tool for Precision Medicine: Automated
  Analysis of Single Cells and the Cellular Microenvironment” - Dr Rupert
  Ecker CEO TissueGnostics GmbH
DTSTART:20180604T130000Z
DTEND:20180604T143000Z
UID:TALK106423@talks.cam.ac.uk
CONTACT:45561
DESCRIPTION:Determining the in-situ immune status of diseased organs or qu
 antify coexpression of molecules on the single-cell level has mostly been 
 subject to visual estimation\, or – at best – to manual counting for d
 ecades. Hence\, experts usually had the choice of the “least of evils”
  between guessing and endless (manual) counting. In tumor immunology\, inf
 iltrating inflammatory cells need to be phenotypically characterized on a 
 quantitative basis. To better understand the function of inflammatory cell
 s in tumor development\, type and number of inflammatory cells and their p
 roximity to glandular/tumor structures have to be analyzed in-situ and cor
 related with disease state. Using TissueFAXS™ Cytometry the time-consumi
 ng and error-prone human evaluation of stained histological sections can b
 e approached with an observer-independent and reproducible technology plat
 form\, offering a high degree of automation\, paired with user interaction
  at relevant points of the analytical workflow. This platform can be appli
 ed as a means of tissue cytometry for both immunofluorescence and immunohi
 stochemistry and thus constitutes the microscopic equivalent to flow cytom
 etry (FACS).\n\nLikewise FACS\, TissueFAXS™ can quantify any type of mol
 ecular marker in any type of cell – but in tissue context or in adherent
  cell culture monolayers without the need to solubilise the cells (i.e. Ti
 ssueFAXS permits analyses in-situ)!\n \nThe TissueFAXS Cytometry platform 
 can be used in clinical multi-center studies to determine the immune respo
 nse to certain drugs in-situ\, measure proliferation\, apoptosis\, cytokin
 e expression\, signalling molecules\, and others. It can do end-point assa
 ys as well as live-cell imaging and time-kinetic experiments. But TissueFA
 XS Cytometry also promotes tissue cytometry to a new level of quality\, wh
 ere complex cellular interactions can be addressed on the single-cell leve
 l but still in histological context. \n
LOCATION:Department of Biochemistry\, Sanger Building Jean Thomas Lecture 
 Theatre
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