BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Polymer Modelling of the 4D Epigenome - Dr Davide Michieletto\; Un
 iversity of Edinburgh
DTSTART:20180726T120000Z
DTEND:20180726T130000Z
UID:TALK106633@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Models of chromosome folding based on polymer physics principl
 es have provided us with much mechanistic insight into the role of transcr
 iption factors and other generic binding proteins in folding the genome. T
 hese models heavily rely on the presence of permanent epigenetic patterns.
  Yet\, we now know that histone post-translational modification and DNA me
 thylation are highly dynamic processes and epigenetic patterns change duri
 ng differentiation\, ageing\, disease and reprogramming. On the other hand
 \, epigenetic patterns are also highly robust\, as they can be remembered 
 after cell division. In order to reconcile these apparently contrasting ob
 servations (epigenetic plasticity and epigenetic memory) we propose a new 
 polymer model in which the 3D diffusion of the chromatin fibre is coupled 
 to time-varying epigenetic states along its backbone. In other words\, we 
 propose the first "4D" polymer model for the epigenome. \nA key prediction
  of our model is that 3D cis/trans interactions are necessary to establish
  and maintain stable epigenetic domains\, which can be remembered even aft
 er major disruptive events such as cell division. By impairing 3D interact
 ions\, we observe that domains can appear only transiently and could not b
 e remembered. Finally\, we observe that epigenetic plasticity can be recov
 ered by including "genomic bookmarks" such as PSC in Drosophila and GATA i
 n humans. Intriguingly\, we find that genomic bookmarks (and not architect
 ural boundaries such as CTCF) are the key elements required to correctly r
 ecapitulate Polycomb domains in Drosophila. Our generic model can be used 
 to explain epigenetic memory after cell division\, but can also be applied
  to cellular ageing and reprogramming.\n\n\nhttps://www2.ph.ed.ac.uk/~dmic
 hiel/
LOCATION:Babraham - The Cambridge Building\; Kings Hedges Room
END:VEVENT
END:VCALENDAR