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SUMMARY:Pub talk: Expression dynamics and positional information during Dr
 osophila segment patterning - Berta Verd (University of Cambridge\, Dept o
 f Genetics) and Erik Clark (University of Cambridge\, Dept of Zoology)
DTSTART:20180612T170000Z
DTEND:20180612T190000Z
UID:TALK106750@talks.cam.ac.uk
CONTACT:Dr David Jörg
DESCRIPTION:The question of how pattern is established during development 
 continues to be one of the most fundamental problems in biology. While muc
 h attention has focused on static mechanisms such as the interpretation of
  morphogen gradients\, it is becoming clear that the temporal dynamics of 
 gene regulatory networks also contribute to pattern formation. In this pub
  talk\, we will illustrate this point with two examples from Drosophila se
 gmentation. These examples\, drawn from our respective PhD projects\, invo
 lve different tiers of the Drosophila segmentation cascade and contrasting
  modelling approaches\, but converge at very similar developmental and evo
 lutionary conclusions. First\, Berta will describe how a quantitative\, da
 ta-driven model of the gap gene network reveals how observed anterior shif
 ts of posterior gap gene domains can be explained as the emergent property
  of an underlying "damped oscillator" regulatory mechanism. Next\, Erik wi
 ll describe how logical modelling of the pair-rule gene network reveals th
 at these gap gene dynamics are in fact crucial inputs for downstream patte
 rning processes. Finally\, we will discuss how these findings help reconci
 le the simultaneous mode of segmentation seen in Drosophila with the ances
 tral\, sequential mode of segmentation that is characteristic of most othe
 r arthropods.
LOCATION:Panton Arms\, 43 Panton St\, Cambridge CB2 1HL
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