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SUMMARY:‘Nuclear Mechanopathology &amp\; Early Cancer Diagnostics’ - P
 rofessor GS Shivashankar\, Deputy Director\, Mechanobiology Institute\, Na
 tional University of Singapore
DTSTART:20180615T093000Z
DTEND:20180615T103000Z
UID:TALK106771@talks.cam.ac.uk
CONTACT:Mala Jayasundera
DESCRIPTION:ABSTRACT: \n\nG.V.Shivashankar: Mechanobiology Institute\, Nat
 ional University of Singapore\, Singapore & FIRC Institute of Molecular On
 cology (IFOM)\, Milan\, Italy\n\nAbnormalities in nuclear and chromatin or
 ganization are hallmarks of many diseases including cancer. In this talk\,
  I will describe our understanding of how the cellular microenvironment re
 gulates nuclear morphology and\, with it\, the spatial organization of chr
 omosomes and genes\, resulting in cell type-specific genomic programs. I w
 ill also discuss the mechanical basis for maintaining nuclear homeostasis 
 and how alterations in nuclear mechanotransduction pathways may result in 
 various diseases. Finally\, I will describe a digital nuclear mechanopatho
 logy platform that uses a multidisciplinary approach combining high resolu
 tion optical imaging\, quantitative single-cell biology\, machine learning
  and functional genomics. Collectively\, our results based on nuclear mech
 anogenomic biomarkers are attractive not only for clinical applications su
 ch as cancer diagnosis\, but also open new avenues for understanding the o
 nset of cancer from a basic science perspective and for the development of
  therapeutic interventions.\n
LOCATION:Sackler Lecture Theatre (Level 7)\, Cambridge Institute for Medic
 al Research
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