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SUMMARY:Alternative Splicing in Tumors: Detection and Interpretation - Ter
 ry Speed (Berkeley)
DTSTART:20080214T160000Z
DTEND:20080214T170000Z
UID:TALK10678@talks.cam.ac.uk
CONTACT:8419
DESCRIPTION:In this talk I will discuss using the Affymetrix GeneChip(R) H
 uman Exon and Human Gene 1.0 ST arrays for the detection of genes spliced 
 differently in some tumors in comparison with others. I plan to begin by i
 ntroducing the arrays and the expression data they produce. Next I will ou
 tline the way in which we use such data in our attempts to identify exon-t
 umor combinations exhibiting splicing patterns different from the majority
 . This will be illustrated by examples from publicly available tissue and 
 mixture data. Then I will briefly discuss some of the additional issues wh
 ich arise when we seek to enumerate such alternative splicing patterns on 
 a genome-wide scale. Finally\, I will exhibit some of the results we have 
 found applying these methods to glioblastoma tissue samples collected as p
 art of The Cancer Genome Atlas (TCGA) project. (This is joint work with EL
 izabeth Purdom\, Mark Robinson\, Ken Simpson\, and members of the Berkeley
  Cancer Genome Center.) \n
LOCATION:MR4\, CMS\, Wilberforce Road\, Cambridge\, CB3 0WB
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