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SUMMARY:Nanotools and materials assembled from DNA - Prof. Tim Liedl\, Lud
 wig-Maximilians-Universität München
DTSTART:20181019T150000Z
DTEND:20181019T160000Z
UID:TALK107437@talks.cam.ac.uk
CONTACT:Lorenzo Di Michele
DESCRIPTION:DNA has proven to be an excellent choice of molecule for progr
 ammable self-assembly. In recent years\, DNA self-assembly has surpassed i
 ts early stages and today is routinely used for constructing functional tw
 o- and three-dimensional nanomachines and materials [1\,2]. \nBy defining 
 attachment sites for active components on DNA structures\, our group has r
 ealised complex and nanometer-precise assemblies of biomolecules\, organic
  fluorophores and inorganic nanoparticles [3\,4]. We employed these device
 s to create new plasmonic effects and I will show how these effects\, in t
 urn\, enable the selective and sensitive detection of proteins and virus-d
 erived RNA molecules [5]. \nThe initial thrust catalyzing the rapid develo
 pment of DNA nanotechnology has been to arrange periodic DNA frameworks to
  host guest molecules for crystal structure analysis. Despite enormous eff
 orts and fundamental progress\, placing guest molecules in designed DNA cr
 ystals remains a challenging goal. By adopting design principles of Ned Se
 eman and Chengde Mao [6]\, we are now able to crystallise DNA origami stru
 ctures that grow into three dimensional\, micrometer-scale assemblies [7].
  Silicification of these crystals leads to designer nanomaterials that wit
 hstand drying without structural deformation. \n\nOur results demonstrate 
 the assembly power of DNA self-assembly and our ability to fabricate funct
 ional devices and 3D materials that are designed on the molecular level wh
 ile reaching macroscopic dimensions.\n\n\n1. P. W. K. Rothemund\, Nature 4
 40\, 297–302 (2006)\n2. N. C. Seeman\, Annu. Rev. Biochem. 79\, 12.1 (20
 10)\n3. R. Schreiber et al. Nature Nanotechnology 9\, 74-78 (2014)\n4. P. 
 Nickels et al. Science\, 354\, 305-307 (2016)\n5. T. Funck et al.\, Angew.
  Chem. Int. Ed.\, 57\, 1-5 (2018) \n6. J. Zheng et al. Nature 461\, 74-77 
 (2009)\n7. T. Zhang et al. Advanced Materials\, doi: 10.1002/adma.20180027
 3 (2018)
LOCATION:Small Lecture Theatre\, Cavendish Laboratory
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