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SUMMARY:Visualizing Electrostatics of a Single Biomolecule in the Fluid Ph
 ase  - Professor Madhavi Krishnan\, University of Oxford
DTSTART:20181114T141500Z
DTEND:20181114T151500Z
UID:TALK108415@talks.cam.ac.uk
CONTACT:Lisa Masters
DESCRIPTION:The desire to “freely suspend the constituents of matter” 
 in order to study their behavior can be traced back over 200 years to the 
 diaries of Lichtenberg. From radio-frequency ion traps to optical tweezing
  of colloidal particles\, existing methods to trap matter in free space or
  solution rely on the use of external fields that often strongly perturb t
 he integrity of a macromolecule in solution. We recently introduced the 
 ‘electrostatic fluidic trap’\, an approach that exploits equilibrium t
 hermodynamics to realise stable\, non-destructive confinement of single ma
 cromolecules in room temperature fluids\, and represents a paradigm shift 
 in a nearly century-old field. The spatio-temporal dynamics of a single el
 ectrostatically trapped object reveals fundamental information on its prop
 erties\, e.g.\, size and electrical charge. We have demonstrated the abili
 ty to measure the electrical charge of a single macromolecule in solution 
 with a precision much better than a single elementary charge. Since the el
 ectrical charge of a macromolecule in solution is in turn a strong functio
 n of its 3D conformation\, our approach enables for the first time precise
 \, general measurements of the relationship between 3D structure and elect
 rical charge of a single macromolecule\, in real time. I will present our 
 most recent advances in this emerging area of molecular measurement and sh
 ow how such high-precision interaction energy measurements at the nanoscal
 e may be able to unveil contributions from previously unanticipated phenom
 ena in intermolecular interactions in solution. \n
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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