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SUMMARY:Mitochondrial dysfunction and signalling in the nervous system - D
 r Joseph Bateman\, Kings College London
DTSTART:20180912T100000Z
DTEND:20180912T110000Z
UID:TALK108454@talks.cam.ac.uk
CONTACT:72232
DESCRIPTION:The overall goal of our work is to understand the effects of m
 itochondrial dysfunction in the nervous system and how this contributes to
  neurodegeneration. Mitochondria are abundant in almost every cell type an
 d are particularly important in the nervous system. Mitochondria generate 
 the majority of cellular ATP but also metabolize fatty acids\, synthesize 
 amino acids\, buffer cellular calcium ions\, produce reactive oxygen speci
 es\, synthesise iron-sulphur clusters and mediate programmed cell death. A
 ltered mitochondrial activity or mitochondrial dysfunction causes ‘mitoc
 hondrial retrograde signalling’ pathways to be activated\, resulting in 
 altered nuclear gene expression. To study mitochondrial retrograde signall
 ing in the nervous system we have developed Drosophila models of neuronal 
 specific mitochondrial dysfunction. I will discuss our recent work where w
 e have shown that mitochondrial dysfunction activates endoplasmic reticulu
 m stress signalling in neurons. We have furthermore used transcriptomics a
 nd metabolomics to identify a novel mechanism\, triggered by mitochondrial
  dysfunction and endoplasmic reticulum stress signalling\, which contribut
 es to loss of neuronal function in Drosophila. This mechanism may be relev
 ant to mitochondrial disease and neurodegenerative diseases associated wit
 h mitochondrial dysfunction.
LOCATION:Sackler Lecture Theatre (Level 7) Wellcome Trust/MRC Building\, C
 ambridge Biomedical Campus
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