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SUMMARY:Drosophila Kinome and Genome-wide RNAi screens reveal novel regula
 tors of epigenetic cell memory - Dr Muhammad Tariq
DTSTART:20180817T110000Z
DTEND:20180817T120000Z
UID:TALK108670@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Cell fate determination\, a fundamental aspect of development 
 in multicellular eukaryotes\, relies on establishment of cell-type specifi
 c gene expression patterns during early development. Once established\, th
 ese patterns are subsequently maintained by two groups of proteins known a
 s Polycomb group (PcG) and Trithorax group (TrxG). Both the PcG and TrxG a
 ssociate with chromatin in the form of multimeric protein complexes to mai
 ntain either a silent or an active states of gene expression\, respectivel
 y. These states are epigenetically inherited through cell division and are
  referred to as cellular memory\, a phenomenon which plays a fundamental r
 ole in cell lineage commitment and differentiation. We have successfully e
 stablished a cell based reporter system in Drosophila which is sensitive t
 o modulation of PcG and TrxG genes. We have exploited our cell based assay
  to perform kinome and genome-wide RNAi screens in Drosophila cells to dis
 cover novel regulators of the epigenetic cell memory. Genetic and molecula
 r characterization of candidate genes discovered in genome-wide RNAi scree
 n have revealed additional histone modifications like phosphorylation and 
 acetylation which influence epigenetic cell memory. In addition to previou
 sly known H3K27 trimethylation and H2AK119ub\, a combinatorial act of addi
 tional histone modifications will be discussed to maintain epigenetic cell
  memory. 
LOCATION:Babraham - The Cambridge Building\; Kings Hedges Room
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