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SUMMARY:Hacking the gene expression machinery for genome defense - Dr Juli
 us Brennecke from IMBA\, Vienna BioCenter 
DTSTART:20181025T130000Z
DTEND:20181025T140000Z
UID:TALK109225@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:There is an ongoing arms race between mobile genetic elements 
 such as transposons and host genome defense systems. Both\, prokaryotes an
 d eukaryotes rely on small RNA pathways for the sequences specific silenci
 ng of transposons and other invading nucleic acids: CRISPR/Cas systems in 
 bacteria and RNA interference pathways in plants\, fungi\, and animals. I 
 will give a conceptual overview of the molecular logic of the Piwi/piRNA p
 athway\, the major transposon silencing system in the animal germline. The
  focus of my talk will be on the intersection of the piRNA pathway with he
 terochromatin biology\, and how evolution found ways to bypass the canonic
 al ways of gene expression.
LOCATION:Biffen Lecture Theatre\, Department of Genetics\, Downing Site
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