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SUMMARY:From molecules to recurrent visual hallucinations: multimodal imag
 ing and computational modelling of Dementia with Lewy bodies - Dr Li Su - 
 Alzheimer’s Research UK Senior Research Fellow
DTSTART:20181128T161500Z
DTEND:20181128T170000Z
UID:TALK109612@talks.cam.ac.uk
CONTACT:jo de bono
DESCRIPTION:Dementia with Lewy bodies (DLB) is an important cause of\ndeme
 ntia in older people. Although it is the second most common\ndegenerative 
 dementia in older people\, it is currently under-studied\ncompared with ma
 ny other forms of dementia\, and very little is known\nabout its underlyin
 g neurobiology. Visual hallucinations is one of\nmain symptoms in DLB affe
 cting over 80% people. Using state-of-the-art brain scan techniques (e.g. 
 Magnetic Resonance Imaging\, multi-tracers positron emission tomography an
 d super sensitive\nmagnetetoencephalography)\, we have measured several im
 portant brain\nchemicals\, brain waves\, and connections between different
  parts of the\nbrain to detect changes in DLB compared with similar aged h
 ealthy\ncontrols and other dementing disease such as Alzheimer’s. In my 
 lab\,\nwe are developing computational models of hallucination in DLB in\n
 order to describe abnormalities found in neural activity and different\nch
 emicals in the brain. The model can predict and show what may happen in th
 e brain during hallucinations on computers. They can also be used to ident
 ify potential therapeutic targets\, and to validate effects of different d
 rug treatments on the symptomology of DLB. Developing new drug treatments 
 by computationally driven approaches is safer\, faster and cheaper by maki
 ng much of the trial-and-error processes virtual before they are tested on
  humans.\n
LOCATION:Lecture Theatre 2\, Computer Laboratory
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