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SUMMARY:Energy Landscapes of Amyloid Oligomers - Luke Dicks\, University o
 f Cambridge
DTSTART:20181017T134000Z
DTEND:20181017T140000Z
UID:TALK109663@talks.cam.ac.uk
CONTACT:Lisa Masters
DESCRIPTION:Amyloid oligomers\, small aggregates of misfolded proteins\, a
 re important in many human diseases\, such as type II diabetes. Despite th
 eir importance in disease\, amyloid oligomers are poorly understood\, due 
 to both transient and polymorphic behaviour making experimental characteri
 sation challenging. Therefore\, computational studies of amyloid oligomers
  have become valuable tools with which to extract structural\, thermodynam
 ic and kinetic properties. In this talk I will explain an improved step-ta
 king scheme in global optimisation of proteins\, and the application of th
 is scheme to locate low-energy conformations of amyloid oligomers. These l
 ow-energy conformations can provide starting points for calculating potent
 ial energy landscapes\, examples of which will be shown for two sets of am
 yloid oligomers.\n\n
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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