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SUMMARY:LMB Seminar Series-Solving a 3D jigsaw with 1000 pieces - Structur
 e and assembly of the nuclear pore complex - Martin Beck
DTSTART:20181203T110000Z
DTEND:20181203T120000Z
UID:TALK109693@talks.cam.ac.uk
CONTACT:72112
DESCRIPTION:LMB Seminar Series-Nuclear pore complexes are fundamental comp
 onents of all eukaryotic cells. They mediate nucleocytoplasmic exchange\, 
 regulate gene expression and are of high human health relevance. Elucidati
 ng their 110 MDa structure imposes a formidable challenge and requires in 
 situ structural biology approaches. How cells address this challenge and a
 ssemble ~1000 building blocks in a faithful manner remains enigmatic. I wi
 ll discuss our efforts to determine the structure of the nuclear pore comp
 lex. I will further present novel insights into the assembly mechanism of 
 nuclear pores that are relevant to oogenesis and early embryonic developme
 nt.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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