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SUMMARY:Comparative glucocorticoid metabolism\; lessons from horses\, huma
 ns and mice - Dr Ruth Morgan\, University of Edinburgh
DTSTART:20181114T160000Z
DTEND:20181114T170000Z
UID:TALK109933@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Activation of the hypothalamic-pituitary-adrenal (HPA) axis an
 d altered tissue glucocorticoid action in obesity\, metabolic syndrome and
  hypertension has been attributed to altered peripheral cortisol metabolis
 m. Our work investigates the role of glucocorticoid metabolism\, transport
  and receptor activation in horses\, humans and mice and the impact of glu
 cocorticoid metabolism on health and disease. We have identified novel pat
 hways of cortisol metabolism in the horse associated with disease and have
  gone on to look at these pathways in humans and in animal models of disea
 se. We focus on predominant cortisol metabolite in horses\, 20β-dihydroco
 rtisol which we have shown to be a preferential agonist of the mineralocor
 ticoid receptor and our current work aims to elucidate the role of this me
 tabolism in obesity associated hypertension in different species. 
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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