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SUMMARY:From nuclear transfer to prospects for cell replacement therapy: T
 he origins and future of pluripotency and cellular reprogramming - Profess
 or Sir John Gurdon\, The Gurdon Institute
DTSTART:20181123T174500Z
DTEND:20181123T191000Z
UID:TALK109987@talks.cam.ac.uk
CONTACT:Dr Antonio M. M. Rodrigues
DESCRIPTION:Abstract -- The different cell types that compose our bodies a
 re remarkably stable.  Hardly ever do we find skin cells in the brain or l
 iver cells in the heart.  In those very special cases where some regenerat
 ion can take place in vertebrates\, there is little if any evidence for a 
 switch in cell-type.  Nevertheless\, nuclear transfer\, cell fusion\, and 
 induced pluripotency can result in pluripotent embryo cells being derived 
 from specialized adult cells.  The mechanisms by which nuclear reprogrammi
 ng can occur in these cases is beginning to be understood.  It may become 
 possible for new\, regenerated cell-types to be derived from adult cells a
 nd given back to a patient so that they receive new cells of their own gen
 etic constitution\, thereby avoiding the need for immunosuppression.  The 
 history of work in this area\, and the prospects for cell replacement in t
 he future will be discussed.\n
LOCATION:Wolfson College - The Lee Hall
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