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SUMMARY:Visualization of low-level Gene Expression and Biomarker Localizat
 ion within Tissue: Applications of RNAscope® and BaseScope - Gemma Hughes
 \; Advanced Cell Diagnostics
DTSTART:20180919T120000Z
DTEND:20180919T123000Z
UID:TALK110005@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Spatially mapped biomarker information at the single-cell leve
 l is crucial to understanding cellular organization and cell-to-cell inter
 actions in complex tissue environment\, and understanding cellular interac
 tions within gene and cell therapy models.\nRNAscope® and BaseScope™ as
 says\, the two highly specific and sensitive ISH methods allow visualizing
  gene expression and genetic variations in tissue environments.\nThis semi
 nar will highlight:\n• Detection of mRNAs\, viral RNAs\, and lncRNAs at 
 single molecule sensitivity by RNAscope® assay\n• Use as cell markers f
 or cell therapy T-cell and viral vector localization as a sensitive safety
  assessment tool\n• Validation of target gene expression after high-thro
 ughput transcriptome analysis\n• Target specific splice junctions by Bas
 eScope™ assay\n• Distinguish specific homologues\, paralogues\, and or
 thologues by RNAscope® or BaseScope™ assays\n• Perform single cell an
 alysis within tissue architecture in FFPE or frozen tissues
LOCATION:Babraham - The Cambridge Building\; Kings Hedges Room
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