BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Exploring the role of ion channels in cancer using executable mode
 lling - Dr Benjamin Hall from MRC Cancer Unit in Cambridge 
DTSTART:20181008T120000Z
DTEND:20181008T130000Z
UID:TALK110092@talks.cam.ac.uk
CONTACT:72001
DESCRIPTION:Ion channels play a major role in a wide range of biological p
 rocesses\, but their role in either cancer development or as an avenue for
  anti-cancer therapeutics is unclear. Dr Hall will show that based on TCGA
  expression data that ion channels are broadly dysregulated in cancer\, an
 d present a network model of channel co-regulation in osmostasis. This mod
 el can predict the known phenotypes of lymph node fibroblast reticular cel
 ls and mouse embryonic fibroblasts with heterozygous and homozygous Kras m
 utations. The model is further capable of predicting the response of these
  cells to protein knockouts by siRNA and in response to drug combinations\
 , and these predictions are validated experimentally.
LOCATION:CRUK CI Lecture Theatre (Room 001)
END:VEVENT
END:VCALENDAR