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SUMMARY:In vitro 3D model for bone tissue: a bioelectronics approach - Dr.
  Donata Iandolo
DTSTART:20181114T130000Z
DTEND:20181114T140000Z
UID:TALK110233@talks.cam.ac.uk
CONTACT:Dr Chris Ness
DESCRIPTION:One of the latest trends in the fields of tissue engineering a
 s well as oncological research is the development of in vitro 3D systems m
 imicking the target tissue or organ. Indeed\, there is an increasing deman
 d for in vitro models recapitulating the three-dimensional structure and m
 icroenvironment experienced by cells in vivo. This approach has manifold a
 pplications in fields such as basic research\, drug discovery\, tissue eng
 ineering\, offering a valid alternative to the use of animals in testing. 
 \nInterestingly\, certain tissues are known to be regulated by endogenous 
 bioelectrical cues\, in addition to chemical and mechanical cues. One such
  tissue is the bone. It has\, indeed\, been demonstrated to exhibit piezoe
 lectric properties in vivo with electrical signalling playing a role in it
 s formation during the early embryo developmental stages. My recent work h
 as been focused on the development of a 3D model based on the conducting c
 onjugated polymer PEDOT:PSS and human stem cells. Indeed\, organic electro
 nic materials offer a unique combination of properties helping to transcen
 d the current state of the art in transduction and stimulation of the elec
 trical activity in cells. In this talk\, I will present the most recent de
 velopments involving 3D electroactive porous scaffolds and their interacti
 on with stem cells. \n
LOCATION:Dept Chemical Engineering and Biotechnology\, Philippa Fawcett Dr
 ive CB3 OAS (Lecture Theatre 3\, Level 3 )
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