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SUMMARY:Deep homology of insect and vertebrate midbrain-cerebellum circuit
 ry - Dr Frank Hirth\, King's College London
DTSTART:20181003T120000Z
DTEND:20181003T130000Z
UID:TALK110317@talks.cam.ac.uk
CONTACT:Kate Criswell
DESCRIPTION:Comparative ground pattern analysis suggests that brains of di
 stantly related animals such as insects and vertebrates are organized simi
 larly but the underlying mechanisms remain elusive. Here we identify a cha
 racter identity network for the Drosophila deutocerebral-tritocerebral bou
 ndary (DTB) comprising genes homologous to those governing vertebrate midb
 rain-hindbrain boundary (MHB) formation. We show the DTB gives rise to Dro
 sophila adult midbrain circuits that mediate body posture and motor contro
 l comparable to vertebrate MHB-derived midbrain-cerebellar circuitry. DTB/
 midbrain-specific gene expression and function is mediated by cis-regulato
 ry elements of inv/En2\, sv/Pax2\, Dachshund/Dach1\, Msx\, Vnd/Nkx2.1\, Em
 x\, Wnt\, FGF8-like\, Ptf1a\, Zinc finger of the cerebellum\, and Purkinje
  cell protein homologs. The DTB-specific regulatory elements exhibit seque
 nce similarities to human regulatory elements that direct MHB-specific exp
 ression in mouse. We propose these gene regulatory networks predate the ra
 diation of the insect and vertebrate-specific DTB and MHB region-derived c
 ircuits and morphologies\, and possibly of the bilaterian cephalic nervous
  systems.
LOCATION:Part II Lecture Theatre\, Department of Zoology
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