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SUMMARY:Epigenetic control of malignant melanoma - Emily Bernstein\, Icahn
  School of Medicine at Mount Sinai
DTSTART:20190221T130000Z
DTEND:20190221T140000Z
UID:TALK110803@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:Cutaneous melanoma is a highly aggressive skin cancer and one 
 of the most challenging cancers in its therapeutic management. Emerging st
 udies demonstrate that cancer is a result of a concerted action of genetic
  and epigenetic alterations. Our understanding of the ‘epigenetic landsc
 ape’ of melanoma remains poorly understood. We have shown a critical rol
 e for histone variants of the H2A family in regulating melanoma pathogenes
 is. For example\, macroH2A acts as a barrier to melanoma growth and metast
 asis (Kapoor et al.\, Nature 2010)\, and H2A.Z.2 promotes melanoma growth 
 by positively regulating transcription of E2F target genes (Vardabasso et 
 al.\, Molecular Cell 2015). Studies will be presented of our ongoing effor
 ts to identify key epigenetic players in melanoma progression and drug res
 istance\, and to decipher the melanoma epigenome by comparing normal melan
 ocytes with malignant melanoma cells. 
LOCATION:CRUK CI Lecture Theatre
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