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SUMMARY:Fire and Water are Good Servants\, But Bad Masters - Tak Mak\, Pri
 ncess Margaret Cancer Centre\, University Health Network\, University of T
 oronto
DTSTART:20190411T120000Z
DTEND:20190411T130000Z
UID:TALK110809@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:It has become clear that tumorigenesis results from much more 
 than just the activation of an oncogene and/or the inactivation of a tumor
 -suppressor gene\, and that the cancer cell genome contains many more alte
 rations than can be specifically targeted at once. This observation has le
 d our group to a search for alternative ways to kill cancer cells (while s
 paring normal cells) by focusing on properties unique to the former. Futur
 e anti-cancer therapeutics will have to be based on exploiting the balance
 s of various biological processes. Three approaches with the potential to 
 generate new anticancer therapies: combatting the tactics by which cancers
  evade antitumor immune responses\, targeting metabolic adaptations that t
 umor cells use to survive conditions that would kill normal cells\, manipu
 lating\, and exploiting aneuploidy. This seminar describes our progress to
  date on these fronts.
LOCATION:CRUK CI Lecture Theatre
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