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SUMMARY:TET-family dioxygenases\, immune responses and cancer  - Anjana Ra
 o\, La Jolla Institute for Allergy and Immunology
DTSTART:20190926T120000Z
DTEND:20190926T130000Z
UID:TALK110815@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:In 2009\, our lab reported that enzymes of the TET (Ten-Eleven
  Translocation) family were a new class of epigenetic regulators that alte
 red the modification status of cytosine bases in DNA. The three mammalian 
 TET enzymes – TET1\, TET2 and TET3 – successively oxidize the methyl g
 roup of 5-methylcytosine (5mC) to yield 5-hydroxymethylcytosine (5hmC)\, 5
 -formylcytosine (5fC) and 5-carboxylcytosine (5caC). These modified cytosi
 ne bases (together termed oxidized methylcytosines\, oxi-mC) facilitate DN
 A demethylation and are also novel epigenetic marks. DNA methylation has l
 ong been linked to developmental processes and to oncogenesis\; similarly 
 TET proteins\, which alter DNA modification status\, are implicated in num
 erous biological processes\, including cell lineage specification\, embryo
 nic development\, immune and neuronal function\, “stemness” somatic ce
 ll reprogramming and cancer. I will discuss the relation between TET activ
 ity\, DNA modification status and oncogenesis in several model systems wit
 h TET loss-of-function. 
LOCATION:CRUK CI Lecture Theatre
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