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SUMMARY:A soft matter perspective on protein self-assembly  - Jennifer McM
 anus - Deparment of Chemistry - Maynooth University
DTSTART:20181116T160000Z
DTEND:20181116T170000Z
UID:TALK111106@talks.cam.ac.uk
CONTACT:Diana Fusco
DESCRIPTION:Controlling the self-assembly of biological molecules to form 
 defined or functional structures with a high degree of predictability is a
  central aim for soft matter science and biological physics. While this is
  possible for a variety of colloidal and nanoscale materials\, it has been
  more difficult to achieve for proteins. In large part\, this is due to th
 e complex nature of the protein surface\, which influences the assembly pr
 ocess. Understanding this complexity is essential to reveal the mechanisms
  underlying important processes such as protein crystallization\, the path
 ogenesis of protein condensation diseases\, the aggregation of proteins du
 ring industrial manufacture and the formation of protein based materials. 
 Using phase diagrams for human gamma D-crystallin (a protein found in the 
 human eye lens)\, I will show that both mutagenesis and chemical modificat
 ion of the protein surface can have a dramatic impact on anisotropic prote
 in-protein interactions and hence the phase behaviour of the protein. \n
LOCATION: Small Lecture Theatre\, Cavendish Laboratory\, J.J. Thomson Aven
 ue
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