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SUMMARY:Babraham Distinguished Lecture - Elucidating new ways to target do
 wnstream of KRAS mutation in colorectal cancer : metabolic and microenviro
 nment targets - Prof. Owen Sansom\; Director of The Beatson Institute for 
 Cancer Research\, University of Glasgow
DTSTART:20190424T130000Z
DTEND:20190424T140000Z
UID:TALK111247@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:My laboratory has spent a number of years understanding the ke
 y consequences of loss of the APC (Adenomatous Polyposis Coli) gene in viv
 o. Loss of the gene is common to most colorectal cancers (80%) and is thou
 ght to initiate CRC. We have found many of our ways to target APC deficien
 t cells stop working when there is additional mutation of KRAS. KRAS is mu
 tated in 40% of CRC and currently acts a negative indicator for EGFR based
  therapies. In my talk\, I will discuss the work we have down investigatin
 g the key mechanistic pathways activated in cells that lose both APC and m
 utate KRAS. I will focus on our work on metabolism and particularly the SL
 C7A5 (LAT1 transporter) that link metabolism into protein synthesis. \n\n 
 \n\nFinally I will discuss our work developing metastatic models of CRC an
 d key determinants of KRAS mutant CRC. Once again these studies have ident
 ified a key role for neutrophils in these models.
LOCATION:Babraham - The Cambridge Building - Petersfield Lecture Theatre
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