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SUMMARY:EU Life Lecture - Temporal scaling of C. elegans Ageing - Dr Nicho
 las E. Stroustrup\; Group Leader - Dynamics of Living Systems\, Centre for
  Genomic Regulation (CRG)\, Barcelona\, Spain
DTSTART:20181211T140000Z
DTEND:20181211T150000Z
UID:TALK111250@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Ageing produces a wide distribution of lifespan even among iso
 genic individuals housed in controlled environments. Using our automated i
 maging platform\, we found that many lifespan-extending interventions prod
 uce a similar effect on the C. elegans lifespan distribution--a temporal s
 caling. Interventions that produce this apparent stretching in respect to 
 time include changes in diet and temperature\, exposure to oxidative stres
 s\, and the disruption of genes including the insulin/IGF receptor\, HSF-1
 \, and DAF-16/FOXO.\n\nThese interventions all produce distinct molecular-
 level changes\, yet ultimately yield a similar scaling of the aging dynami
 cs.  To understand this phenomenon\, we ran a series of simulations in whi
 ch we found that temporal scaling can arise as a general response of highl
 y-interconnected complex networks.  When components (e.g molecular mechani
 sms) are embedded in highly-interconnected networks\, declines in the func
 tion of small sub-networks can propagate to yield a homogeneous effect on 
 the dynamics of the system as a whole.  These results a provide a new\, em
 pirically-grounded framework for linking molecular interventions to their 
 systemic effects in aging.
LOCATION:Babraham - The Cambridge Building - The Kings Hedges Room
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