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SUMMARY:Data-driven approaches to drug target identification - Dr Alex Gut
 teridge (GSK)
DTSTART:20181017T130000Z
DTEND:20181017T140000Z
UID:TALK111550@talks.cam.ac.uk
CONTACT:46925
DESCRIPTION:Abstract: The selection of a drug target is the first step of 
 a process that consumes huge quantities of time and money in both academia
  and the biotech and pharma industries\, but truly objective data driven a
 pproaches to this problem are still in their infancy. In this seminar I wi
 ll review the approaches we take in GSK to identify and validate drug targ
 ets through integrative analysis of large scale 'omic and epidemiological 
 data. Our approach is rooted in the causal inferences made possible by adv
 ances in human genetics\, including GWAS and Mendelian Randomisation\, but
  also includes epigenetics\, transcriptomics and network biology. I will f
 inish by describing the Open Targets collaboration between GSK\, Biogen\, 
 the Wellcome Trust Sanger Institute and the European Bioinformatics Instit
 ute. Open Target's mission is to both generate and integrate genome-scale 
 data in support of target identification and validation and is committed t
 o openly sharing data with the scientific community through publications\,
  internationally recognised databases and the Open Targets Platform. 
LOCATION:MR4\, Centre for Mathematical Sciences\, Wilberforce Road\, Cambr
 idge
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