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SUMMARY:Redefining microglia states in health and disease - Hammond Timoth
 y - Boston Children's Hospital\, Harvard Medical School
DTSTART:20181011T110000Z
DTEND:20181011T120000Z
UID:TALK111883@talks.cam.ac.uk
CONTACT:Dr Romina Vuono
DESCRIPTION:\nShort bio:\n\nTim received his Ph.D. from George Washington 
 University in Washington\, DC where he worked in the lab of Dr. Vittorio G
 allo to investigate glial signaling in white matter disorders. He then joi
 ned the lab of Dr. Beth Stevens as a postdoc at Boston Children's Hospital
  in Boston where he has been investigating microglia development\, signali
 ng and state changes using single cell RNAseq and high throughput spatial 
 mapping of novel microglia populations.\n\nAbstract:\n \nMicroglia\, the r
 esident immune cells of the brain\, rapidly change states in\nresponse to 
 their environment\, but we lack molecular and functional signatures of dif
 ferent microglial populations. In this study\, we analyzed the RNA express
 ion patterns of more than 76\,000 individual microglia during development\
 , old age and after brain injury. Analysis uncovered at least nine transcr
 iptionally distinct microglial states\, which expressed unique sets of gen
 es and were localized in the brain using specific markers. The greatest mi
 croglial heterogeneity was found at young ages\; however\, several states 
 including chemokine-enriched inflammatory microglia persisted throughout t
 he lifespan or increased in the aged brain. Multiple reactive microglial s
 ubtypes were also found following demyelinating injury in mice\, at least 
 one of which was also found in human MS lesions. These unique microglia si
 gnatures can be used to better understand microglia function and to identi
 fy and manipulate specific subpopulations in health and disease.
LOCATION:James Fawcett Seminar Room\, van Geest Building
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