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SUMMARY: Exploiting stochastic fluctuations to understand cellular process
 es and infer biochemical kinetics - Dr Andreas Hilfinger (University of To
 ronto)
DTSTART:20181010T130000Z
DTEND:20181010T140000Z
UID:TALK111985@talks.cam.ac.uk
CONTACT:46925
DESCRIPTION:Abstract: Many biological processes in cells are complex yet s
 parsely characterized. Constructing models of such systems then often requ
 ires making many assumptions based on guesswork. Instead of ignoring or gu
 essing unknown details in complex processes I will present universal balan
 ce relations to rigorously characterize stochastic fluctuations in incompl
 etely specified systems. Specifying some features of a system while leavin
 g everything else unspecified allows us to establish physical performance 
 bounds for classes of intracellular processes. Additionally\, we can turn 
 general network invariants into experimental data analysis tools. For exam
 ple\, exploiting naturally occurring cell-to-cell variability allowed us t
 o test specific hypotheses about gene expression\, showing that observed f
 luctuations in E. coli contradict the majority of published models of stoc
 hastic gene expression.\n\n
LOCATION:MR4\, Centre for Mathematical Sciences\, Wilberforce Road\, Cambr
 idge
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