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SUMMARY:Expanding the Genetic Code to Address Biomedical Challenges       
    - Dr Charlie Morgan
DTSTART:20181018T121000Z
DTEND:20181018T130000Z
UID:TALK112129@talks.cam.ac.uk
CONTACT:Holly
DESCRIPTION:Genetic code expansion enables site-specific incorporation of 
 designer amino acids into proteins produced in cells and animals. Recent i
 nnovations in the efficiency of unnatural amino acid incorporation is enab
 ling researchers to study the function and regulation of cellular proteins
  with extraordinary molecular level insights being achieved. Our chemical 
 genetic approach will be discussed that utilizes expanded genetic code tec
 hniques to direct small molecule ligands to a single protein of interest. 
  Incorporation of an unnatural amino acid into a disease-causing protein e
 nables for the rapid visualization or inducible control of the protein. Cu
 rrent research efforts will be shared that utilize the unique biorthogonal
  reactivity between the unnantural amino acid and small molecules to drive
  rapid\, potent\, and selective kinase inhibition in cells.  The ability t
 o selectively and rapidly interrogate the function of single proteins in h
 ealthy and disease cells is a central role in efforts to develop new perso
 nalized medicines.
LOCATION:The Richard King Room\, Darwin College
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