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SUMMARY:Cell Uptake and Trafficking: from amyloid proteins to drug deliver
 y vehicles - Prof. Elin K. Esbjörner\, Department of Biology and Biologic
 al Engineering\, Chalmers University of Technology\,  Sweden
DTSTART:20181005T130000Z
DTEND:20181005T140000Z
UID:TALK112171@talks.cam.ac.uk
CONTACT:Ryan Limbocker
DESCRIPTION:Cellular uptake and membrane trafficking are ubiquitous proces
 ses of all eukaryotic cells that collectively function to sort\, transport
 \, degrade\, and communicate proteins and other cargoes within and between
  cells. Dysfunctions to membrane trafficking systems are common findings i
 n neurodegenerative disease\, and processes such as endocytosis\, exocytos
 is\, and exosome release seem to play a role in cell-cell transfer of amyl
 oid proteins and aggregates. My group focuses on understanding how amyloid
  proteins interact with cellular machineries for uptake and trafficking. I
 n this talk I will present data on how the uptake and cell interactions of
  Aβ and α-synuclein species depend on their aggregation state\, but also
  show recent work on fluorescent TDP-43 cell models to study prion-like pr
 opagation related to ALS. Membrane trafficking processes can also be utili
 sed for drug delivery purposes\, as the main route of uptake of biological
  drugs (e.g. proteins and nucleic acids)\; we currently study this in the 
 context of lipid-mediated mRNA delivery and in this talk I will show some 
 recent results and strategies focused on understanding mechanisms of uptak
 e and endosomal escape.
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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