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SUMMARY:Control across scales by positive and negative feedback - Rodolphe
  Sepulchre\, University of Cambridge
DTSTART:20181213T140000Z
DTEND:20181213T150000Z
UID:TALK112210@talks.cam.ac.uk
CONTACT:Alberto Padoan
DESCRIPTION:Feedback is a key element of regulation\, as it shapes the sen
 sitivity of a process to its environment. Positive feedback up-regulates\,
  negative feedback down-regulates. Many regulatory processes involve a mix
 ture of both\, whether in nature or in engineering. This talk will revisit
  the mixed feedback paradigm\, with the aim of investigating control acros
 s scales. We propose that mixed feedback regulates excitability and that e
 xcitability plays a central role in multi-scale signalling. We analyse thi
 s role in a multi-scale network architecture inspired from neurophysiology
 . The nodal behavior defines a meso-scale that connects actuation at the m
 icro-scale to measurements at the macro-scale. We show that mixed-feedback
  control at the nodal scale provides regulatory principles at the network 
 scale\, with a nodal resolution. In this sense\, the mixed feedback paradi
 gm is a control principle across scales. 
LOCATION:Cambridge University Engineering Department\, Lecture Theatre 2
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