BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Sensing enhanced by DNA nanotech - Prof. Philip Tinnefeld\, Ludwig
  Maximilians-Universität München
DTSTART:20190308T160000Z
DTEND:20190308T170000Z
UID:TALK112309@talks.cam.ac.uk
CONTACT:Lorenzo Di Michele
DESCRIPTION:In recent years\, DNA nanotechnology has matured to enable rob
 ust production of complex nanostructures and hybrid materials. We have com
 bined DNA nanotechnology with sensitive optical detection to create functi
 onal single-molecule devices that enable new applications in single-molecu
 le biosensing and superresolution microscopy. Starting with superresolutio
 n nanorulers and brightness reference samples we determined the resolving 
 power of superresolution microscopes and evaluated the sensitivity of smar
 tphone cameras. To improve the sensitivity\, we created DNA origami optica
 l antennas for metal enhanced fluorescence. The unique ability of our DNA 
 origami nanoantennas to place molecular assays specifically in the plasmon
 ic hotspot is used for detecting Zika-virus and antibiotic resistance rela
 ted nucleic acids. Furthermore\, DNA origamis are used in biophysical assa
 ys to work at locally increased concentrations\, to apply forces as well a
 s to sense further physical parameters.
LOCATION:Ryle Seminar Room\, Cavendish Laboratory
END:VEVENT
END:VCALENDAR