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SUMMARY:Description: A good Aβ? Bioinorganic perspective on the toxicity 
 and physiological role of beta-amyloid peptides - Prof Wojcieh Bal 
DTSTART:20181120T130000Z
DTEND:20181120T140000Z
UID:TALK112741@talks.cam.ac.uk
CONTACT:Dr Arkadiusz Bonna
DESCRIPTION:Formation of toxic aggregates and plaques consisting of beta-a
 myloid (Aβ) peptides is a generally acknowledged early event in Alzheimer
 ’s Disease. This fact prompted the development of numerous therapies foc
 using on inhibition of Aβ synthesis or dissolution of Aβ-derived structu
 res. These therapies do not work\, and it seems that Aβ elimination is as
  detrimental to brain function as its excess. A distinct line of research 
 connects mechanisms of Aβ toxicity with copper physiology\, postulating t
 he Cu(Aβ) complexes as important toxic species acting via oxidative stres
 s.\n\nWe revisited the Aβ/copper relationship taking into account sequenc
 e heterogeneity of this family of peptides. Our studies resulted in a prop
 osal of physiological function for Aβ4-x peptide subfamily as synaptic co
 pper scavengers and shuttles. This concept helps explain the failures of A
 β-directed therapeutic approaches\, set limits on applicability of chelat
 ion therapies in neurodegenerative diseases and assist development of nove
 l ideas in AD treatment.
LOCATION:Department of Biochemistry\, Sanger Building Jean Thomas Lecture 
 Theatre
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