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SUMMARY:Bordetella autotransporters: virulence factors\, vaccine candidate
 s and models for unraveling type V secretion mechanisms - Dr Rachel Fernan
 dez\, University of British Columbia\, Vancouver\, Canada
DTSTART:20080407T120000Z
DTEND:20080407T130000Z
UID:TALK11316@talks.cam.ac.uk
CONTACT:Duncan Maskell
DESCRIPTION:Autotransporters are a major class of outer membrane proteins 
 in Gram-negative bacteria. They function as virulence factors (e.g. adhesi
 ns and proteases)\, are implicated in biofilm formation\, and have been us
 ed to bioengineer heterologous functional modules on bacterial surfaces. A
 utotransporters also provide a model to examine fundamental biological que
 stions of how proteins cross membranes. There are ~ 30 autotransporters pr
 esent in Bordetella bronchiseptica\, B. pertussis\, B. parapertussis and B
 . avium. \n\nIn this seminar I will provide an overview of the Bordetella 
 autotransporters\, dissect the secretion of the B. pertussis BrkA autotran
 sporter\, and discuss the protective capacity of BrkA in the murine lung c
 olonization model.  \n\n
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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