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SUMMARY:How space constrains evolution: lessons from bacteria and bacterio
 phage - Dr Diana Fusco
DTSTART:20181114T140000Z
DTEND:20181114T150000Z
UID:TALK113434@talks.cam.ac.uk
CONTACT:46925
DESCRIPTION:Abstract: \nSpatially growing populations are ubiquitous acros
 s scales\, ranging from microbial biofilms in the soil to expanding tissue
 s in developing organs and the spreading of diseases. In spatial settings\
 , individuals experience inhomogeneities in the surrounding environment th
 at result in different growth rates across the population. Since replicati
 on is necessary to transmit the genetic information from mother to daughte
 r\, the growth dynamics determined by the spatial constraints can deeply a
 ffect the spreading of mutations in a population and thus its evolution.\n
 \n \n\nHere\, I will present two examples in which the simple spatial cons
 traints associated with two-dimensional growth affect both the genetic div
 ersity and the adaptation of microbial and viral populations\, respectivel
 y. Population sequencing and fluorescence imaging show that microbial colo
 nies exhibit an excess of mutational jackpot events compared to a well-mix
 ed population of the same size. At the same time\, they also carry a large
  number of rare mutations that are homogeneously distributed across the po
 pulation and continuously generated during the growth process. A very diff
 erent growth and evolutionary dynamics is instead observed in ecoliphage T
 7 two-dimensional plaques. Here the phage has to find an optimal incubatio
 n time\, which provides a sufficient offspring number without excessively 
 delaying its diffusion.
LOCATION:MR4\, Centre for Mathematical Sciences\, Wilberforce Road\, Cambr
 idge
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