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SUMMARY:Dynamics of Spinal Cord Development - Theory &amp\; Experiments - 
 James Briscoe (Francis Crick Institute) &amp\; Karen Page (University Coll
 ege London)
DTSTART:20181018T170000Z
DTEND:20181018T190000Z
UID:TALK113446@talks.cam.ac.uk
CONTACT:Dr. Adrien Hallou
DESCRIPTION:The generation of the correct cell types at the appropriate po
 sition and time is the first step in the assembly of functional tissues. O
 ne well studies example is the development of the vertebrate spinal cord. 
 In this tissue\, distinct neuronal subtypes are generated in a precise spa
 tial order from progenitor cells arrayed along the dorsal-ventral axis of 
 the neural tube. Underpinning this organization is a complex network of ex
 trinsic and intrinsic factors. Particularly well understood is the mechani
 sm that determines the generation of different neuronal subtypes in ventra
 l regions of the spinal cord. In this region of the nervous system\, the s
 ecreted protein Sonic Hedgehog (Shh) acts in graded fashion to organize th
 e pattern of neurogenesis. This is a dynamic process in which exposure to 
 Shh generates progenitors with successively more ventral identities. At th
 e same time tissue growth alters the arrangement of cells and the proporti
 ons of cell types and contributes to the elaboration of pattern. A gene re
 gulatory network composed of transcription factors regulated by Shh signal
 ing play an essential role in determining the graded response of cells. Th
 us\, accurate patterning of the neural tube and the specification of neuro
 nal subtype identity relies on the interplay of cellular and molecular pro
 cesses.
LOCATION:Sainsbury Laboratory\, Bateman Street\, Cambridge CB2 1NN
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