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SUMMARY:Cancer Genome Evolution and Immune Escape - Dr Nicholas McGranahan
  from Francis Crick Institute in London
DTSTART:20181112T130000Z
DTEND:20181112T140000Z
UID:TALK114073@talks.cam.ac.uk
CONTACT:72001
DESCRIPTION:Lung cancer is the leading cause of cancer-related mortality w
 orldwide. Large-scale sequencing studies have revealed the complex genomic
  landscape of NSCLC and genomic differences between lung adenocarcinomas (
 LUAD) and lung squamous cell carcinomas (LUSC). However\, in-depth explora
 tion of NSCLC intra-tumour heterogeneity and cancer genome evolution has b
 een limited to small retrospective cohorts. As such\, the clinical signifi
 cance of ITH\, the potential for clonality of driver events to guide thera
 peutic strategies is not yet defined\, and the interplay between the cance
 r cell and the immune system remains poorly understood. \nIn his talk Dr N
 icholas McI will outline how intra-tumour heterogeneity can be deciphered 
 using multi-region sequencing. He will examine how heterogeneity can be ut
 ilized to gain a deeper understanding of tumour evolution\, focusing on th
 e importance of large scale copy number alterations\, including whole-geno
 me doublings and mutational process generating heterogeneity. He will also
  explore the interaction between cancer genome evolution and anti-tumour i
 mmunity and mechanisms of immune escape. \n
LOCATION:Room 215\, CRUK Cambridge Research Institute
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