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SUMMARY:Direct from sputum sequencing of TB in the field\, and connecting 
 them to a global google. - Dr Zamin Iqbal\, Research Group Leader\, The Eu
 ropean Bioinformatics Institute (EMBL-EBI)
DTSTART:20190313T160000Z
DTEND:20190313T170000Z
UID:TALK114148@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Routine full characterization of Mycobacterium tuberculosis (T
 B) is culture-based\, taking many weeks. Whole-genome sequencing (WGS) can
  generate antibiotic susceptibility profiles to inform treatment\, and unl
 ike traditional tests\, also delivers strain information which can be used
  for local epidemiology and global surveillance\; such data could be trans
 formative if provided at or near point of care.\n In the first half of my 
 talk\, I will talk about our recent work developing methods for low-cost e
 xtraction of DNA direct from respiratory samples\, and integration with Il
 lumina and Oxford Nanopore sequencing technologies\, with potential for ap
 plication in the field. In the second half\, I will address the question o
 f how to tie point-of-care diagnostics in with global surveillance in a wo
 rld where whole-genome sequencing -based diagnostics take off. I ask what 
 challenges must computational biologists solve to enable true global surve
 illance of bacteria\, coping with  open pan-genomes\, outbreaks\, evolving
  resistance and Joe Medic as a user of our tools. I will describe and demo
 nstrate our cloud-based solution that will scale to millions of bacteria. 
 \n
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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