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SUMMARY:Molecular Studies in Vascular Dementia - Atticus Hainsworth\, St G
 eorge's University of London
DTSTART:20181107T103000Z
DTEND:20181107T113000Z
UID:TALK114541@talks.cam.ac.uk
CONTACT:Gabriella Heller
DESCRIPTION:Damage in brain blood vessels contributes to cognitive impairm
 ent in most cases of Alzheimer’s disease. Vascular dementia is the secon
 d most common dementia subtype after Alzheimer’s. Unlike Alzheimer’s d
 isease where culprit molecules are well established\, notably APP-derived 
 beta-amyloid and hyper-phosphorylated tau protein\, brain vascular disease
  lacks molecular targets and urgently needs better chemistry.\n\nAtticus H
 ainsworth’s group test molecular hypotheses in human brain tissue and in
  experimental models. We are especially interested in brain endothelial ce
 lls\, blood-brain barrier dysfunction and white matter lesions. We recentl
 y completed a phase II clinical trial\, testing the phosphodiesterase inhi
 bitor drug tadalafil for possible repurposing in vascular dementia.
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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