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SUMMARY:Jockeying for position: defining Streptococcus equi gene essential
 ity in the horse - Dr Andrew Waller\, Animal Health Trust\, Newmarket
DTSTART:20190130T160000Z
DTEND:20190130T170000Z
UID:TALK114742@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Strangles\, caused by Streptococcus equi\, is one of the most 
 frequently diagnosed infectious disease of horses worldwide. We defined th
 e global population structure of this important host-restricted pathogen r
 evealing a population replacement in the late 19th or early 20th century a
 nd providing new insights into the epidemiology of outbreaks at local\, na
 tional and international levels. \n\nGenome information was exploited to d
 evelop a new multicomponent subunit vaccine\, Strangvac\, that protected 9
 5% of ponies two weeks after third vaccination. However\, protection fell 
 after 2 months and further improvements to strangles vaccines are required
 . \n\nRecently\, we developed a barcoded transposon directed insertion-sit
 e sequencing (TraDIS) functional genomics platform for S. equi. The barcod
 ed TraDIS method minimised the effects of stochastic loss and facilitated 
 the identification of 368 genes that were required for fitness in Welsh mo
 untain ponies. These genes included four of the eight components of Strang
 vac\, suggesting that TraDIS can inform vaccine design.\n
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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