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SUMMARY:BSU Seminar: “Estimation in two-stage adaptive threshold enrichm
 ent clinical trials” - Dr Peter Kimani\, University of Warwick
DTSTART:20181129T133000Z
DTEND:20181129T143000Z
UID:TALK114868@talks.cam.ac.uk
CONTACT:Alison Quenault
DESCRIPTION:It is now widely acknowledged that a patient’s characteristi
 cs may predict how they respond to treatments. Consequently several clinic
 al trials assess the treatment effect in the full population and in biomar
 ker-defined subpopulations. If a biomarker is continuous\, a two-stage ada
 ptive threshold enrichment trial incorporates determining the best thresho
 ld for defining a subpopulation. Stage 1 data are used to perform an inter
 im analysis to determine if the new treatment is promising in the full pop
 ulation or in a subpopulation defined by one of the candidate biomarker th
 reshold values. In stage 2\, recruitment is restricted to the promising su
 bpopulation. In this talk I will describe how to obtain point estimators t
 hat adjust for subpopulation selection associated with including stage 1 d
 ata in the confirmatory analysis.
LOCATION:Small Seminar Room\, 1st Floor\, Institute of Public Health\, Uni
 versity Forvie Site\, Robinson Way\, Cambridge
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