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SUMMARY:How to start a procentriole - Professor Andrew Goryachev\, Univers
 ity of Edinburgh
DTSTART:20181127T130000Z
DTEND:20181127T140000Z
UID:TALK114937@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:Centrioles are crucial cellular organelles that form cores of 
 centrosomes and cilia. Centrioles must replicate once every cell cycle pro
 ducing exactly one daughter centriole. Both failure to replicate and produ
 ction of supernumerary centrioles jeopardizes cellular life and can cause 
 disease\, such as microcephaly and cancer. Temporary regulation of centrio
 le replication\, which is provided by the cell cycle\, has been largely el
 ucidated. However\, the numeric control that ensures that only one procent
 riole is produced by each pre-existing centriole remains an unsolved puzzl
 e. \n\nIn this talk I will present our theoretical model of the centriole 
 initiation process. We postulate that a small module comprising a kinase P
 LK4 and its activator-substrate STIL/Ana2/SAS-5 is the core of the protein
  network responsible for the initiation of a procentriole. Our model recap
 itulates symmetry-breaking transition in the spatial localization of PLK4 
 from a symmetric ring surrounding mother centriole to a single spot markin
 g the position of nascent procentriole. Importantly\, our model predicts t
 hat induction of a single procentriole is not just an advantageous happens
 tance but the result of winner-takes-all competition between multiple cent
 riolar loci for the PLK4-STIL complexes. Weakening of competition by overe
 xpression of PLK4 and STIL causes progressive addition of supernumerary pr
 ocentrioles\, as has been observed experimentally.\n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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