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SUMMARY:Simulation of Intimal Thickening in Arteries by Morphoelasticity -
  Pak-Wing Fok (University of Delaware)
DTSTART:20181203T130000Z
DTEND:20181203T140000Z
UID:TALK115150@talks.cam.ac.uk
CONTACT:Anne Herrmann
DESCRIPTION:Atherosclerosis is a manifestation of cardiovascular disease c
 onsisting of the buildup of inflamed arterial plaques. Because most heart 
 attacks are caused by the rupture of unstable "vulnerable" plaque\, the ch
 aracterization of plaques and their vulnerability remains an outstanding p
 roblem in medicine.\n\nMorphoelasticity is a mathematical framework common
 ly employed to describe tissue growth. Its central premise is the decompos
 ition of the deformation gradient into the product of an elastic tensor an
 d a growth tensor. In this talk\, I will present some recent efforts to si
 mulate intimal thickening -- the precursor to atherosclerosis -- using mor
 phoelasticity theory.\n\nThe arterial wall is composed of three layers: th
 e intima\, media and adventitia. The intima is allowed to grow isotropical
 ly while the area of the media and adventitia is approximately conserved. 
 All three layers are modeled as anisotropic hyperelastic materials\, reinf
 orced by collagen fibers. We explore idealized axisymmetric arteries as we
 ll as more general geometries that are solved using the finite element met
 hod. Results are discussed in the context of balloon-injury experiments on
  animals and Glagovian remodeling in humans.\n
LOCATION:MR11\, Centre for Mathematical Sciences\, Wilberforce Road\, Camb
 ridge
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