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SUMMARY:Food allergen-sensitized CCR9+ lymphocytes enhance airways allergi
 c inflammation in mice - Dr Laure Castan\; Laboratory of Antoine Magnan\, 
 Centre Hospitalier\, Universitaire de Nantes\, Nantes\, France 
DTSTART:20181122T130000Z
DTEND:20181122T140000Z
UID:TALK115228@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:The mechanisms of the atopic march\, characterized by a natura
 l progression from food and cutaneous allergies to allergic rhinitis and a
 sthma\, are still unknown. However\, as several organs can be involved\, c
 hemokines and their receptors might be implicated in this process and may 
 be instrumental factors.\nObjectives: We hypothesized that the T-cell gut-
 homing receptor CCR9 could be implicated in the evolution of allergic dise
 ases.\nMethods: We characterized the immune response and the role of CCR9 
 in a murine model combining food allergy to wheat gliadin and a model of a
 cute airways inflammation in response to house dust mite.\nResults: Compar
 ed with solely asthmatic-like mice\, we demonstrated that the aggravation 
 of pulmonary symptoms in consecutive food and respiratory allergies\, char
 acterized by an increase in pulmonary resistance and a higher Th17/Treg ra
 tio\, was abrogated in CCR9 knockout mice. Moreover\, transfer of food-all
 ergic CD4+ T cells from wild-type but not from CCR9-/- aggravated airways 
 inflammation demonstrating that CCR9 is involved in food allergy-enhanced 
 allergic airway inflammation to unrelated allergens.\nConclusion: Taken to
 gether\, our results demonstrated a crucial role of the T-cell homing rece
 ptor CCR9 in this model and validated its potential for use in the develop
 ment of therapeutic strategies for allergic diseases.
LOCATION:Babraham - The Cambridge Building - Kings Hedges Room
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