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SUMMARY:Primary and Secondary Prevention of Dementia: can we PROTECT our C
 ognitive Health? - Professor Clive Ballard\, Professor of Age-related Dise
 ases\, College of Medicine and Health\, University of Exeter
DTSTART:20190523T113000Z
DTEND:20190523T123000Z
UID:TALK115351@talks.cam.ac.uk
CONTACT:Dr Muzaffer Kaser
DESCRIPTION:As the number of people with dementia continues to grow\, and 
 we are still making limited headway in the development of disease modifyin
 g therapies\, the potential role of prevention is becoming increasingly im
 portant.  Our understanding of key factors associated with increased and r
 educed risk of dementia has become increasingly clear through recent meta-
 analysis and there is some evidence that prevention measures are already b
 eginning to mitigate incident rates of dementia within each age group.  To
  maximize potential benefits for public health however\, we need to have m
 echanisms to evaluate and implement evidence based approaches in a cost-ef
 fective way.  To this end we have developed the PROTECT platform – an on
 -line cohort study in people without dementia over the age of 50\, running
  in the UK\, US\, Norway and Hong Kong. We currently have 25\,000 UK parti
 cipants with serial neuropsychology\, mental health assessments\, lifestyl
 e and medical information and DNA -  and the cohort will grow to over 100\
 ,000 people over the next year with the international federation. So far\,
  we have been able to confirm the increased risk of hearing loss and depre
 ssion as risk factors for cognitive decline\, highlight the importance of 
 mild behavioural impairment as a key risk factor for progressive decline a
 nd begin to identify potential genetic mechanisms and produce evidence dem
 onstrating the benefit of cognitive training in 2 large RCTs using differe
 nt training approaches\, with ongoing trials of vitamin D\, physical exerc
 ise and nutritional interventions.
LOCATION:Seminar Room\, Herchel Smith Building\, Forvie Site.
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