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SUMMARY:G I TAYLOR LECTURE - Fluctuations in the life of a cell: maintaini
 ng order amidst disorder - Professor Vikram Deshpande\, Department of Engi
 neering
DTSTART:20190128T180000Z
DTEND:20190128T190000Z
UID:TALK115792@talks.cam.ac.uk
CONTACT:Beverley Larner
DESCRIPTION:Living cells evade thermodynamic decay aided by the exchange o
 f nutrients with their environment. They thus are quintessential examples 
 of out-of-equilibrium systems but nevertheless maintain a homeostatic stat
 e over a timescale of hours to days. However\, these nutrient exchanges al
 so fuel large non-thermal fluctuations of cells and we use this observatio
 n to motivate a statistical thermodynamic theory for the homeostatic equil
 ibrium of adherent cells. Numerous\, sometimes counterintuitive observatio
 ns\, of cell behaviour can be rationalised in the context and we shall dis
 cuss a few examples. For instance\, “contact guidance”- the widely-kno
 wn phenomenon of cell alignment induced by anisotropic environmental featu
 res and an essential first step in the organization of cells to form tissu
 es will be presented as an example whereby cells attain a specific type of
  order by maximising their overall disorder.
LOCATION:Bristol-Myers Squibb Lecture Theatre\, Department of Chemistry
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