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SUMMARY:A V HILL LECTURE - Cardiac Arrest:  From Genes to Mechanisms to Mi
 nd - A V HILL LECTURE -  Professor Pier Lambiase FRCP FHRS\, Professor of 
 Cardiology\, UCL\, London and St Barts London
DTSTART:20190225T180000Z
DTEND:20190225T190000Z
UID:TALK115801@talks.cam.ac.uk
CONTACT:Beverley Larner
DESCRIPTION:This lecture will give an overview of the mechanisms of abnorm
 al heart rhythm disorders leading to “Cardiac Arrest” i.e. ventricular
  fibrillation. The lecture will be divided into 3 areas: Genes\, Mechanism
 s and the Mind –examining the role of heart-brain interactions. \n\nInit
 ially\, cardiac ion channel mutations in inherited cardiac conditions will
  be discussed examining both Long QT syndrome and Brugada Syndrome respect
 ively.  I will then focus on the role of “molecular autopsy’ in young 
 sudden death cases and its application to family screening. Whole exome st
 udies of the cardiovascular genes give a diagnostic yield of about 30% but
  there is a challenge in determining the pathogenicity of a number of vari
 ants.  Studies have been extended to population level data and our “Elec
 trogenomics” Group has discovered 30 new loci regulating heart rate duri
 ng exercise and recovery in 70\,000 subjects from UK Biobank.\n\nVentricul
 ar arrhythmias arise from the initiation of re-entry around regions of fun
 ctional block. Identifying these sites and predicting their initiation rem
 ains a major challenge with implications for both targeting treatment and 
 risk stratification. The molecular basis for cardiac alternans will be pre
 sented showing data from simultaneous cardiac mapping and targeted biopsy 
 studies during open heart surgery. We have undertaken a number of studies 
 in inherited and acquired cardiac conditions and shown that the dynamic ch
 anges in conduction and repolarisation can be used to predict ventricular 
 arrhythmia locations using invasive mapping of the heart and non-invasive 
 ECG Imaging.  The ultimate goal will be to plan non-invasive ablation comb
 ined with CT/MRI imaging of the heart to target pro-arrhythmic sites.\n\nI
 t is well recognised that anxiety and stress can promote cardiac arrest an
 d I will present data from studies we have undertaken in the cardiac cathe
 terisation laboratory demonstrating the effects of mental stress\, movies 
 and music on cardiac electrophysiology.\n\n
LOCATION:Bristol-Myers Squibb Lecture Theatre\, Department of Chemistry
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