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SUMMARY:On a fish's eye development in 3D - Anne Herrmann (University of C
 ambridge)
DTSTART:20181206T130000Z
DTEND:20181206T140000Z
UID:TALK115834@talks.cam.ac.uk
CONTACT:Anne Herrmann
DESCRIPTION:In developing pseudostratified epithelia\, nuclei move repeate
 dly between the apical and basal surfaces of cells. This process is termed
  interkinetic nuclear migration (IKNM) and has been studied extensively in
  the brain\, retina and spinal cord of multiple organisms. But despite the
 se efforts many questions about the precise mechanism of IKNM remain. Base
 d on in vivo light sheet microscopy we develop a quantitative model for th
 e phenomenological properties of IKNM in the retinal system. Both the data
  and our model support the hypothesis of IKNM being a stochastic process d
 uring the majority of the cell cycle. Furthermore\, our model reveals the 
 remarkable and previously overlooked importance of simple physical constra
 ints imposed by the overall tissue architecture. Because IKNM has been sug
 gested to fulfil a regulatory role for retinal cell differentiation\, our 
 results have important implications for understanding proper eye developme
 nt. Moreover\, our findings will inform future work on IKNM in other organ
 s and on the developmental regulation in these systems.
LOCATION:MR11\, Centre for Mathematical Sciences\, Wilberforce Road\, Camb
 ridge
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