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SUMMARY:Cellular Conversations that Control Cancer - Thea D Tlsty\, Univer
 sity of California San Francisco (UCSF) Helen Diller Comprehensive Cancer 
 Center and Department of Pathology\, 513 Parnassus Avenue\, San Francisco\
 , CA 94143-0511
DTSTART:20190426T120000Z
DTEND:20190426T130000Z
UID:TALK115981@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:A wealth of evidence has demonstrated that the microenvironmen
 t in which a tumorigenic cell evolves is as critical to its evolution as t
 he genetic mutations it accrues. We found that carcinoma-associated fibrob
 lasts (CAFs)\, and the distinct ECM they deposit\, can cause increased dis
 semination and metastasis\, while healthy fibroblasts constrain these trai
 ts. A defining molecular characteristic of CAFs is their repression of CD3
 6 and the reprogramming of adjacent cells in the stromal microenvironment 
 that ensues. Using both in vitro and in vivo assays\, we demonstrated that
  CD36 repression is necessary and sufficient to recapitulate the pro-tumor
 igenic phenotypes observed in desmoplasia.  Consistent with a functional r
 ole for this coordinated\, multi-cellular program in tumorigenesis\, we ob
 served that clinical outcomes were strongly associated with low CD36 expre
 ssion. Modulating CD36 may be a valuable tool in prevention and interventi
 on of carcinogenesis. 
LOCATION:CRUK CI Lecture Theatre
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